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Congenital ophthalmic diseases, or congenital eye diseases, are a group of vision impairments or blindness that manifest at birth or during early infancy, often resulting from genetic mutations or developmental anomalies in the eye. These conditions can affect various structures of the eye, including the cornea, retina, and optic nerve, and can lead to severe visual impairment or complete blindness. The impact of these diseases on individuals and their families is profound, emphasizing the urgent need for effective therapeutics and therapies.