Antibodies, the extraordinary proteins that serve as the frontline troops of the human immune system, have recently gained attention for their ability to combat tiny compounds known as haptens. Because of their small size, these elusive targets present particular difficulty for the immune system to identify as foreign invaders. However, researchers' inventiveness has resulted in the creation of...
Breast cancer, a widely recognized term, stands as one of the most prevalent malignant tumors among women. Nevertheless, the medical community remains captivated by the elusive origins of breast cancer. In recent years, scientists have shifted their focus towards the microscopic world within cells, particularly honing in on the protein synthesis factories within cells – ribosomes....
In a groundbreaking announcement on October 2nd, the Nobel Assembly revealed the recipients of the 2023 Nobel Prize in Physiology or Medicine: scientists Katalin Karikó and Drew Weissman. Their revolutionary research in messenger ribonucleic acid (mRNA) has had a profound impact on vaccine development, particularly during the COVID-19 pandemic. The duo's work has not only saved numerous...
In response to COVID-19 outbreaks, mRNA vaccine technology has been rapidly developed and successfully applied. the standard method of immunization with the SARS-CoV-2 mRNA vaccine consists of two intramuscular injections of immunization at 21 or 28 days intervals, followed by a booster immunization several months later.
Advantages of mRNA vaccines include:
* Strong immunogenicity against CD8+...
Tauopathies, a group of diseases characterized by pathological changes in tau proteins, including Alzheimer's disease (AD), share a common hallmark: intracellular neurofibrillary tangles (NFTs) composed of hyperphosphorylated aggregates of tau protein.
A recent groundbreaking study, featured in the journal Science and conducted by researchers at the University of Pennsylvania, has identified a...
Lyme disease is a tick-borne infection caused by the bacteria Borrelia burgdorferi, which can cause neurological damage, arthritis, and heart disease if left untreated. By researching the infection process, a team from the University of Maryland discovered that an ancient signaling system serves an unanticipated function in connecting immunity to tick development in a recent paper published in...
The continued emergence of SARS-CoV-2 variants and breakthrough infections following vaccination underscore the need to study the effectiveness of current COVID-19 vaccines in the real world.
To date, only two mRNA COVID-19 vaccines have been approved for marketing, mRNA-1273 developed by Moderna and BNT162b2 developed by Pfizer/BioNTech, which have proven to be very effective in preventing...
Therapeutics based on macromolecular proteins and peptides have successfully been efficiently applied to treat serious human diseases. With the development of biotechnologies, a great number of authorized protein therapeutics and drug products have been utilized in clinical research over the last few decades. However, the main issue that needs to be resolved...
For several decades, CNS diseases have caused serious burdens for individuals with these diseases in both physical and mental health. Studies show that more than 95% of CNS diseases have an unknown etiology, which presents scientists with significant obstacles on the road to the creation of efficient treatments. Parkinson's disease and Alzheimer's disease are the two most common types of...
In the past few decades, both pharmaceutical companies and academia have spent much financial resources and energy to improve the practicability and accuracy of in vitro screening technology that can test the biological activity and physicochemical properties of compounds. However, the study of potential drug candidates in animal models remains disposable.
FDA, NMPA, and other regulatory...
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